Epilepsy:

[1] Cunha JM, Carlini EA, Pereira AE, et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients.Pharmacology. 1980;21(3):175-185. doi:10.1159/000137430

Pain:

[2] Xu DH, Cullen BD, Tang M, Fang Y. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.Curr Pharm Biotechnol. 2020;21(5):390-402. doi:10.2174/1389201020666191202111534

[3] Frane N, Stapleton E, Iturriaga C, Ganz M, Rasquinha V, Duarte R. Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study.J Cannabis Res. 2022;4(1):47. Published 2022 Aug 24. doi:10.1186/s42238-022-00154-9

[4] Mazzantini C, El Bourji Z, Parisio C, et al. Anti-Inflammatory Properties of Cannabidiol and Beta-Caryophyllene Alone or Combined in an In Vitro Inflammation Model.Pharmaceuticals (Basel). 2024;17(4):467. Published 2024 Apr 7. doi:10.3390/ph17040467

Anxiety:

[5] Dahlgren MK, Lambros AM, Smith RT, Sagar KA, El-Abboud C, Gruber SA. Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial.Commun Med (Lond). 2022;2(1):139. Published 2022 Nov 2. doi:10.1038/s43856-022-00202-8

[6] Berger M, Li E, Rice S, et al. Cannabidiol for Treatment-Resistant Anxiety Disorders in Young People: An Open-Label Trial.J Clin Psychiatry. 2022;83(5):21m14130. Published 2022 Aug 3. doi:10.4088/JCP.21m14130

[7] Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series.Perm J. 2019;23:18-041. doi:10.7812/TPP/18-041

[8] Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.Transl Psychiatry. 2014;4(7):e408. Published 2014 Jul 8. doi:10.1038/tp.2014.53

Sleep:

[9] Kisiolek JN, Flores VA, Ramani A, Butler B, Haughian JM, Stewart LK. Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity.Nutrients. 2023;15(19):4173. Published 2023 Sep 27. doi:10.3390/nu15194173

[10] Chagas MH, Eckeli AL, Zuardi AW, et al. Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series.J Clin Pharm Ther. 2014;39(5):564-566. doi:10.1111/jcpt.12179

[11] Hsiao YT, Yi PL, Li CL, Chang FC. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.Neuropharmacology. 2012;62(1):373-384. doi:10.1016/j.neuropharm.2011.08.013

Stress:

[12] Henson JD, Vitetta L, Quezada M, Hall S. Enhancing Endocannabinoid Control of Stress with Cannabidiol.J Clin Med. 2021;10(24):5852. Published 2021 Dec 14. doi:10.3390/jcm10245852

[13] Crippa JAS, Zuardi AW, Guimarães FS, et al. Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial.JAMA Netw Open. 2021;4(8):e2120603. Published 2021 Aug 2. doi:10.1001/jamanetworkopen.2021.20603

[14] Lookfong NA, Raup-Konsavage WM, Silberman Y. Potential Utility of Cannabidiol in Stress-Related Disorders.Cannabis Cannabinoid Res. 2023;8(2):230-240. doi:10.1089/can.2022.0130

Neuroprotection:

[15] Singh J, Neary JP. Neuroprotection Following Concussion: The Potential Role for Cannabidiol.Can J Neurol Sci. 2020;47(3):289-300. doi:10.1017/cjn.2020.23

[16] Pazos MR, Mohammed N, Lafuente H, et al. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.Neuropharmacology. 2013;71:282-291. doi:10.1016/j.neuropharm.2013.03.027

Acne:

[17] Oláh A, Tóth BI, Borbíró I, et al. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.J Clin Invest. 2014;124(9):3713-3724. doi:10.1172/JCI64628

[18] Martinelli G, Magnavacca A, Fumagalli M, DellʼAgli M, Piazza S, Sangiovanni E. Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids.Planta Med. 2022;88(7):492-506. doi:10.1055/a-1420-5780

Magnesium:

[19] Reno AM, Green M, Killen LG, O'Neal EK, Pritchett K, Hanson Z. Effects of Magnesium Supplementation on Muscle Soreness and Performance. J Strength Cond Res. 2022;36(8):2198-2203. doi:10.1519/JSC.0000000000003827

[20] Zhang J, Zhang B, Zhang J, Lin W, Zhang S. Magnesium Promotes the Regeneration of the Peripheral Nerve. Front Cell Dev Biol. 2021;9:717854. Published 2021 Aug 11. doi:10.3389/fcell.2021.717854

Topical benefits of Essential Oils:

[21] de Cássia da Silveira E Sá R, Lima TC, da Nóbrega FR, de Brito AEM, de Sousa DP. Analgesic-Like Activity of Essential Oil Constituents: An Update. Int J Mol Sci. 2017;18(12):2392. Published 2017 Dec 9. doi:10.3390/ijms18122392

Safety of CBD in dogs:

[22] Di Salvo A, Conti MB, Della Rocca G. Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge. Front Vet Sci. 2023;10:1204526. Published 2023 Jun 30. doi:10.3389/fvets.2023.1204526

Bioavailability of CBD:

[23] Saals BADF, De Bie TH, Osmanoglou E, et al. A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women. Sci Rep. 2025;15(1):3678. Published 2025 Jan 29. doi:10.1038/s41598-025-87621-4

Benefits of Arnica:

[24] Widrig R, Suter A, Saller R, Melzer J. Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study. Rheumatol Int. 2007;27(6):585-591. doi:10.1007/s00296-007-0304-y